Urm1 at the crossroad of modifications

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Urm1 at the crossroad of modifications

The ubiquitin-like protein Urm1 can be covalently conjugated to other proteins, such as the yeast thioredoxin peroxidase protein Ahp1p, through a mechanism involving the ubiquitin E1-like enzyme Uba4. Recent findings have revealed a second function of Urm1 as a sulphur carrier in the thiolation of eukaryotic cytoplasmic transfer RNAs (tRNAs). Interestingly, this new role of Urm1 is similar to t...

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ژورنال

عنوان ژورنال: EMBO reports

سال: 2008

ISSN: 1469-221X,1469-3178

DOI: 10.1038/embor.2008.209